Sleep disorder, chorea, and dementia associated with IgLON5 antibodies

Sleep disorder, chorea, and dementia associated with IgLON5 antibodies

A novel syndrome characterized by a distinctive sleep disorder accompanied by variable symptoms of brainstem involvement and a highly restricted haplotype was recently described in association with antibodies to a neuronal cell adhesion protein named IgLON5. Because of the symptoms and chronic disease progression, most of these patients are primarily seen by specialists in sleep and neurodegene...

Sleep disorder associated with antibodies to IgLON5: parasomnia or agrypnia?

Sleep disorder associated with antibodies to IgLON5: parasomnia or agrypnia?-Authors' reply.

We read with great interest the paper by Lidia Sabater and colleagues, who describe a novel neuroimmuno logical disease that is a complex, severe sleep disorder associated with antibodies to IgLON5. We have noted a clinically similar disorder in a single patient who had serum and CSF antibodies to the metabotropic GABAB receptor. Similar to the patients in Sabater and colleagues’ report, our pa...

A novel NREM and REM parasomnia with sleep breathing disorder associated with antibodies against IgLON5: a case series, pathological features, and characterization of the antigen

Lidia Sabater, PhD1,*, Carles Gaig, MD1,2,3,*, Ellen Gelpi, MD1,4,*, Luis Bataller, MD5,7, Jan Lewerenz, MD6, Estefanía Torres-Vega, BSc7, Angeles Contreras, MD8, Bruno Giometto, MD9, Yaroslau Compta, MD2, Cristina Embid, MD3,10, Isabel Vilaseca, MD3,11, Alex Iranzo, MD1,2,3, Joan Santamaría, MD1,2,3, Josep Dalmau, MD1,12,13, and Francesc Graus, MD1,2 1Institut d'Investigacions Biomèdiques Augu...

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.

The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele fre...